Scientists have long suspected a connection between obesity and diabetes, but were unable to determine the details of the relationship.

Until now.

According to a recent study published in the journal Cell Metabolism, fat cells secrete PEDF (pigment epithelium-derived factor), a protein that, when released into the bloodstream, desensitizes the muscle and liver to insulin. The pancreas must then produce more insulin to compensate. Because it becomes overworked, the pancreas eventually slows down or stops releasing insulin altogether, which can lead to Type 2 Diabetes. Overweight individuals tend to be less responsive to insulin, and thus need more to maintain their body’s regulation of blood glucose.

The study results showed that while an increase in PEDF causes Type 2 diabetes, obstructing it actually reverses the effects – when PEDF was blocked, subjects became more responsive to insulin, and thus did not need a surplus of it to keep their systems regulated.

Now that this direct causal link between obesity and diabetes has been discovered, researchers can begin working on a new drug that will successfully prevent and treat Type 2 diabetes. Weight loss is certainly an effective means of averting and managing diabetes as well.

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